Can I Take Plavix and Aspirin at the Same Time
What is Aspirin? How Aspirin was made?
Aspirin is a Brand name for a medicine that contains acetyl salicylic acid as an active ingredient. This drug reduces substances in the body that crusade pain, fever, and inflammation. It is used as a mild pain and fever reliever. Aspirin as well inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.
This medicine is often prescribed in club to forestall and care for conditions after heart attacks, to prevent strokes, and to treat arthritis or inflammation. Aspirin is available in an over-the-counter (OTC) and prescription class, with diverseness of brand names, but it can exist besides constitute in many combination products.
This drug is available in dissimilar forms, including: tablet, picture show coated tablet, chewing-gum, Rectal suppository or chewable tablet. It is bachelor in doses of 81 mg, 325 mg and 500 mg.
Aspirin is the offset synthetic substance made in 1853, by chemist Charles Frédéric Gerhardt who treated sodium salicylate from willow tree leaves with acetyl chloride to produce acetylsalicylic acrid for the first time.
Earlier that salicylic acrid has been used for centuries in the course of leaves from the willow tree, due to its health benefits. In 1897, scientists at Bayer University started studying acetylsalicylic acid equally a more efficient, safer and less-irritating replacement for common salicylic acid medicines.
By 1899, Bayer had named the drug Aspirin and was selling it around the world. Aspirin was Bayer's make name; however, Bayer'south rights to the trademark were lost or sold in many countries. FDA approved Bayer Aspirin in 1965.
Aspirin uses
Aspirin indications are:
- Pain
- Rheumatoid arthritis
- Thromboembolism
- Stroke
- Transient Ischemic Set on
- Astute Coronary Syndrome
- Cardiovascular Event
- Cardiovascular Disease
- Tension headache
- Migraine
- Arthritis
- Colorectal Cancer
- Juvenile Idiopathic Arthritis
- Pericarditis
- Polycythemia vera
- Spondyloarthropathies
- Systemic lupus erythematosus
- Colorectal adenomas
- Kawasaki disease
- Preeclampsia
What is Plavix? What is Plavix used for?
Plavix is a Brand name for a medicine that contains clopidogrel as an active ingredient. This drug prevents platelets from sticking together in the blood and forming a blood clot that can occur with certain heart or blood vessel conditions. Plavix is often prescribed due to following a heart assault or stroke. Plavix is also used to treat and prevent attacks of unstable angina pectoris or peripheral artery disease.
Using Plavix in combination with aspirin is constructive in preventing another heart assail, but this combination may increase your hazard of haemorrhage. It is besides known that clopidogrel is associated with rare but serious side drug reactions including severe neutropenia, hemorrhage and cardiovascular edema.
Your doctor will make up one's mind initial Plavix dose based on your condition. The maintenance dose is 75 mg taken by mouth i time per day. Plavix is bachelor in the form of tablet and film coated tablets in doses of 75 mg and 300 mg. FDA canonical clopidogrel in 1997. It is originally manufactured past Bristol-Myers Squibb and Sanofi.
Plavix indication is reduction of atherosclerotic events in patients with:
· Myocardial infarction
· Stroke
· Established peripheral arterial disease
· Angina
Aspirin Vs clopidogrel (Plavix) mechanism of action
The platelet aggregation-inhibiting effect of Aspirin specifically involves its power to work equally an acetyl donor to enzyme cyclooxygenase – COX. Withal, non-acetylated salicylates accept no clinically significant upshot on platelet aggregation. Irreversible acetylation of cyclooxygenase renders this enzyme inactive, preventing the formation of the aggregating molecule thromboxane A2 in platelets.
Since platelets got no the power to synthesize new proteins, anti-aggregative furnishings remains for the life of the exposed platelets which is most 7-10 days.
Acetylsalicylic acid may likewise inhibit product of prostacyclin (PGI2), which is the platelet aggregation inhibitor, in blood vessel endothelial cells; but, inhibition of prostacyclin is not permanent, considering endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.
Clopidogrel is a prodrug, so it must be metabolized by CYP450 enzymes in tehe liver to produce the active metabolite that than inhibits platelet assemblage. Clopidogrel's active metabolite prevents bounden of ADP – adenosine diphosphate to platelet receptor sites, thus impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa circuitous which is necessary for platelet aggregation.
It is suggested that this inhibition induce a mobilization blockade from the storage sites of the platelet granules to the outer membrane. Clopidogrel irreversibly and specifically inhibits the P2Y12 subtype of ADP receptor, of import in plateletsaggregation and cross-linking past the protein fibrin. Equally the glycoprotein GPIIb/IIIa complex is fibrinogen'south major receptor its dumb function prevents fibrinogen actions and inhibits platelet aggregation.
Differences and similarities betwixt Aspirin and Plavix
Aspirin and Plavix have many differences merely their biggest similarity is their property to inhibit platelet aggregation in the body.
Chemically these drugs are dissimilar. Aspirin is derivative of benzoic acid and belongs to the grade of phenol esters. Clopidogrel from Plavix belongs to the grade of organic compounds known equally alpha amino acrid esters.
The other difference is in their mechanism of action. Aspirin works past inhibiting COX enzyme, while clopidogrel works by impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa.
Compared to aspirin, Plavix is besides prescribed as secondary prevention of atherosclerotic events in patients with a history of stroke, myocardial infarction, peripheral vascular illness and in those at high run a risk of vascular events who accept major contraindications to aspirin. Nonetheless, in most those cases, aspirin is first line therapy while Plavix is a second line.
Plavix tin exist also prescribed for mail off-pump CABG (beating-centre surgery) and post coronary artery stenting but only on temporarily basis. The FDA has not approved Plavix for the treatment of atrial fibrillation arrhythmias, while aspirin has been approved. However, many studies showed that clopidogrel has almost the aforementioned or even better efficacy compared for aforementioned aspirin indications.
When patients who could non tolerate aspirin are switched to Plavix, they probably causeless that the risk of Plavix side effects would be almost like to, if not less than, comparable with aspirin. Even with a higher risk of Plavix to cause stomach bleeding, they would take assumed that Plavix was as constructive equally aspirin with similar safety.
Absorption after aspirin oral administration is generally rapid and consummate simply may vary depending on dosage form, tablet dissolution rate and gastric or intraluminal pH. Assimilation of clopidogrel is at least 50% based on urinary excretion of its metabolites. Bioavailability of clopidogrel is non affected by nutrient. Both drugs have excessive potential for protein binding with a range of 98-99.5 %.
Protein bounden will exist decreased in situations when plasma salicylate concentration increases, during reduced plasma albumin concentrations, renal dysfunction, and during pregnancy. Aspirin is rapidly metabolized via hydrolysis primarily in the liver to salicylic acrid, which is and then conjugated with glycine forming salicyluric acid and glucuronic acrid which are largely excreted in the urine.
Clopidogrel also has hepatic metabolism which is all-encompassing and rapid. It is a prodrug form of drug which is hydrolyzed to carboxylic acrid derivative, the main circulating metabolite, which accounts for approximately 85% of the circulating drug-related compounds.
A glucuronic acid derivative has been also found in plasma and urine. Metabolites do not have platelet inhibiting effect. Aspirin elimination one-half-life time is approximately 15 minutes, as the dose increases from 300 to 650 mg one-half-life increases to 3.1 to 3.ii hours. Clopidogrel elimination one-half-life time is about 8 hours.
Which drug is more constructive according to studies, Apirin or Plavix?
CAPRIE trial (The Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events) compared 75 mg of clopidogrel to 325 mg of aspirin in about nineteen,000 patients with symptomatic vascular disease, with contempo ischemic stroke that happened in a time between1 week to 6 months, and myocardial infarction within 35 days or documented peripheral arterial illness.
Clopidogrel was associated with a significant 8.7% relative adventure reduction among all patients and compared with aspirin for the primary end point of ischemic stroke, myocardial infarction, or vascular death (5.32% chance after clopidogrel use compared with 5.83% risk after aspirin utilise per twelvemonth).
The benefit of clopidogrel confronting aspirin was best achieved in patients with peripheral arterial disease (3.71% adventure after clopidogrel apply vs iv.86% risk later aspirin use per year. Trial besides found that the benefit after clopidogrel apply was not statistically meaning in comparison with aspirin (vii.fifteen% gamble after clopidogrel vs 7.71% run a risk after aspirin utilise per year).
Risks of causing hemorrhage were like between the groups. Overall relative benefit of clopidogrel over aspirin according to CAPRIE trial was modest with absolute risk reduction of 0.5% per year.
Combination therapy of aspirin + clopidogrel has been shown to be more constructive than aspirin or clopidogrel monotherapy in patients with acute myocardial infarction, unstable angina, or coronary interventions. This combinationt is used commonly, especially for patients with coronary avenue disease.
1 report of aspirin has been shown 23% risk reduction for recurrent nonfatal stroke compared with placebo, and has determined aspirin as antiplatelet medication for stroke prevention.
Studies of clopidogrel take found an 8% relative hazard reduction of stroke recurrence, equally compared with aspirin, among stroke patients. Studies of aspirin plus dipyridamole have suggested relative take chances reductions of 20 to 23% in comparision with aspirin alone
Aspirin Vs Plavix side effects
| Aspirin possible side effects | Plavix possible side furnishings |
|---|---|
| Angioedema | Upper respiratory tract infection (8.7%) |
| Bronchospasm | Chest hurting (eight.3%) |
| CNS alteration | Headache (7.half-dozen%) |
| Dermatologic problems | Flulike syndrome (seven.v%) |
| GI hurting, ulceration, haemorrhage | Arthralgia (six%) |
| Hepatotoxicity | Pain (6%) |
| Hearing loss | Dizziness (6%) |
| Nausea | Diarrhea (4.5%) |
| Platelet aggregation inhibition | Rash (4.2%) |
| Premature hemolysis | Rhinitis (4.2%) |
| Pulmonary edema (salicylate-induced, noncardiogenic) | Depression (3.six%) |
| Rash | Urinary tract infection (3.1%) |
| Renal harm | Astringent neutropenia (<ane%) |
| Tinnitus | Thrombotic thrombocytopenic purpura (<1%) |
| Urticaria | Acute liver failure (<1%) |
| Vomiting | Aplastic anemia (<1%) |
| Hypotension (<1%) | |
| Hepatitis (<ane%) | |
| Myalgia (<1%) | |
| Eczema (<1%) | |
| Erythema (<1%) | |
| Agranulocytosis (<1%) |
Which one is expensive, Aspirin or Plavix?
According to drugs.com:
· The toll for Aspirin tablet 325 mg is effectually $six.4 for a supply of xx tablets
· The toll for Aspirin chewable tablet 81 mg is around $half dozen.8 for a supply of 36 chewable tablets
· The cost for Aspirin rectal suppository 300 mg is around $xix for a supply of 12 suppositories
· The toll for Aspirin rectal suppository 600 mg is around $19.6 for a supply of 12 suppositories
· The toll for Plavix tablet 75 mg is around $204.six for a supply of 30 tablets
· The toll for Plavix tablet 300 mg is around $828 for a supply of 30 tablets
Prices depend on the pharmacy you visit. Prices are for greenbacks paying customers only and are non valid with insurance plans.
Warnings and precautions during Aspirin and Plavix use
- Before taking aspirin, you should tell tour doctor if you have or have ever had: Asthma, uncommonly frequent stuffed or runny nose, nasal polyps, frequent heartburn, upset breadbasket, or stomach pain, ulcers, anemia, gout, diabetes some liver or kidney affliction, hemophilia or any other bleeding conditions.
- You should talk to your physician before giving aspirin to a child or teenager nether 16 years. The medicine tin cause a serious and sometimes fatal condition known as Reye's syndrome if it given to a child recovering from chickenpox or flu-like symptoms.
- Before having any type of surgery, including dental procedures tell your doctor yous are taking aspirin.
- Y'all should non take aspirin for pain treatment during a period longer of ten days or to treat a fever that lasts longer than three days, because such symptoms may be a signal for more serious status.
- If you lot take aspirin on abiding basis to preclude a heart attack or stroke, you shouldn't take ibuprofen or other non-steroidal anti-inflammatory drugs such equally naproxen or diclofenac to treat pain without consulting your doctor first.
- Aspirin may crusade stomach or intestinal bleeding and ulcers. Older adults may exist more sensitive to aspirin side effects.
- Since Plavix works by inhibiting platelets aggregation, it increases the likelihood of serious bleeding even after minor injury
- Your doctor should perform certain claret tests before yous use Plavix to brand sure that y'all don't have any genetic atmospheric condition that would make it dangerous for you to take
- you lot should not utilise Plavix if you have a stomach ulcer or a head injury that has caused bleeding in the encephalon,
- Your dentist and doctor should know if you are taking Plavix, to exist sure that surgery can exist safely performed
- Patients allergic to Plavix should not apply this drug
- Talk to your md about whatever allergies you might take after taking medicines like prasugrel (Effient), ticlopidine (Ticlid) or ticagrelor (Brilinta) so that dr. can be sure that Plavix is prophylactic to be taken.
- Patients with wellness disorders involving bleeding or a blood-clotting disorder like trombocytopenic purpura or hemophilia should talk with their doctor before using Plavix
- Patients should also tell their doctor if you always accept a history of stroke, including mini-strokes known every bit transitory ischemic attacks, ulcerative colitis, stomach ulcers and kidney disease.
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Source: https://drugsdetails.com/aspirin-vs-plavix/
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